TMT's medium speed and thin removal density (one to two playable spells per color) give the leaves-the-battlefield trigger the room it needs: bodies stick long enough to block, and when removal does arrive, the Mutagen lands as compensation rather than nothing. That makes this a P1P5 to P1P7 pick in BG Food, where the Mutagen reads as a second sacrifice fuse. The format's food subtheme already wants artifacts to feed and chump bodies to spend, and a 2/2 that becomes both ends at once is a structural fit, not a synergy hope.
GU is the other real home, and it values the card on the back end rather than the front. The body itself is a vanilla 2/2 with no evasion, so it does not enable anything on attack; what GU wants is the recursion loop, any flicker or bounce effect that farms a second Mutagen off a creature that was already going to die. In a blue-green draft that opens that way, it climbs toward P1P4. RW Equipment is the lowest-priority home despite the artifact overlap with Bespoke Bō and Novel Nunchaku; that deck wants raw damage on curve, and a counter that costs three mana and two turns to deliver is the wrong tempo shape for its clock.
The punisher is Stomped by the Foot, which every black drafter runs and which kills the 2/2 cleanly. Even so, the Mutagen means the trade favors you on cards: they spent removal, you kept a counter engine. Maindeck in any green deck with a sacrifice outlet; flex in mono-curve green draws that just want bodies.
