Void Rend

The tension every catch-all removal spell has to resolve is that it dies to the same interaction it exists to punish: you spend three mana to answer the threat, and a one-mana counter answers you first. This one bolts the door before the argument starts. The uncounterable clause is not a bonus riding on top of the destroy effect; it is what you are actually buying when you pay three colored pips for what a single black spell can otherwise do. Against a control mirror or a permission-heavy opponent, resolution is the scarce resource, and a removal spell that guarantees its own resolution rewrites the exchange: the answer to your answer has to be another permanent, not a two-mana instant on the stack. The cost is steep and specific. Three pips, one of each color in the Esper shard, is a real deckbuilding tax that fences this into decks already committed to white, blue, and black, and the "destroy" verb leaves it soft against indestructible permanents and against anything that would rather be exiled than killed. But within that fence it delivers the one thing generic removal cannot promise: it lands. The lineage here runs through every removal spell that ever got Counterspelled at the worst moment; this is the version built so that the person casting it, not the person holding up mana, decides whether the trade happens.