Pick the Brain

Targeted discard with a memory-erasure clause attached, and that clause is what separates this from every other hand-attack spell. The base mode is a more selective Coercion: you see the hand, you take the best nonland card, and you accept the premium a full three mana buys over Duress-style one-drops in exchange for stripping creatures and planeswalkers too. Delirium is where it turns from a fair-rate exchange into a combo-hate tool. Once your graveyard holds four card types, the exiled card stops being one copy gone and becomes every copy gone: hand, graveyard, and library all searched and stripped of anything sharing that name, the rest shuffled away. That is the structural difference between disrupting a single combo piece and dismantling a deck built around four copies of it. The setup is what you pay. Delirium asks you to fill a graveyard with varied types before the card pays its best dividend, which means the surgical version only comes online in a deck already invested in self-mill or fetch-and-crack value, not the dedicated control shell that would most want the effect. Cast early it is a selective one-card swap with a good look at the hand; cast late, with the graveyard primed, it is a clean answer to anything that wins by drawing the same card over and over.