Gift of Tusks
Stripping abilities and resetting the body are the same effect here, fired by a single blue instant. Blue does not normally answer a creature outright: it bounces, it counters, it taxes. This sidesteps that color constraint by neutralizing rather than removing. A 9/9 trampler with a relevant activated ability becomes a vanilla 3/3 Elephant, which is enough to swallow it in combat, flip a race, or defang an attacker you have no clean way to kill. Because the spell changes what the creature is rather than dealing it damage, indestructible offers no shelter against the combat math that follows; the lost abilities take the activated and triggered engines down with them. The catch is that it still says target creature, so hexproof and protection keep their owners safely out of range, exactly as they would against any other targeted spell. It belongs to the same lineage as Turn to Frog and the other shrink-to-a-small-vanilla-body tricks, but where Turn to Frog leaves a 1/1, this hands you a 3/3, large enough to brawl with most attackers and to stand as a real blocker. The reach comes at a price paid in duration: the transformation expires with the turn, making it a combat tool and a stack-of-the-moment answer, not a permanent solution. Pointed at your own undersized blocker it becomes a pump spell into a 3/3 body; pointed at a problem creature mid-combat it is a one-mana wrench thrown into the works.
